We are working on the functions of oncogenic viruses, chromatin organization and metabolism in normal cells, cancer and genetic diseases.

HIV-1 Tat protein remodels the nuclear organization of B-cells. Germini et al., Leukemia, 2017      ©VZ

Yegor VASSETZKY and Svetlana DOKUDOVSKAYA

UMR8126

CNRS - Université Paris-Sud - Institut Gustave Roussy

Address: Pavillons de Recherche 1, 39, rue Camille-Desmoulins, 94805 Villejuif, France
Email:   vassetzky@igr.fr
            svetlana.dokudovskaya@gustaveroussy.fr
Phone:  +33142116283

The HIV-1 Tat protein induces MYC  relocalization next to IGH in normal B-cells
Germini et al, Leukemia, 2017, DOI: 10.1038/leu.2017.106
HIV-1 Tat protein remodels the nuclear organization of B-cells thus incerasing the probality of apperance of Burkitt lymphoma. More…

A one-step PCR-based assay to evaluate efficiency and precision of genomic DNA -editing tools
Germini et al., Mol. Ther. 2017 5:43-50
A rapid and simple method to evaluate whether CRISPR/Cas9 works on your selected  target. More…

SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.
Dokudovskaya and Rout, 2016, J Cell Sci. 15:2219-28
The highly conserved target of rapamycin complex 1 (TORC1) controls eukaryotic cell growth and response to a variety of signals and plays the key role in the regulation of autophagy. Upstream, it is regulated by a  newly discovered multiprotein SEA complex, also known as GATOR. More…