Fourth International Meeting
"Early events in Human Pathologies"
12-16 October 2011
Yerevan, Armenia
Wednesday, October 12
Arrival to Yerevan
21:00 Bus to Ani Plaza Hotel
Thursday, October 13
8:30 – 9:30 Breakfast
9:30 – 9:45 Registration
9:45 – 10:00 Transfer to the National Academy of Sciences
10:00 – 10:30 Opening ceremony
Armen GALOYAN, President of the Armenian Association of Biochemists
Yegor VASSETZKY, GDRI coordinator
10:30-11:30 Session 1. Chromatin and transcription
Chairmen: Liliane Massade and Tigran Davtyan
SAYP and Brahma are important for “repressive” and “transient” Pol II promoter-proximal pausing.
Sonia Georgieva
Co-temporal replication and transcription in long genes induces common fragile site breakage that can be prevented by inhibiting R-loop formation
Laszlo Tora
Selective cytotoxicity and modification activity of picornaviruses on transformed cell lines
Z.A.Karalyan
11:30-11:50 Coffee Break
11:50-13:10 Session 2. Nucleus
Chairmen: Marc Lipinski and Vadim Kavsan
Nuclear organization in lymphoid cells: implications for translocations and gene regulation
Yegor Vassetzky
Dynamic nature of active chromatin hubs
Sergey Razin
Treatment of lymphoid cells with the topoisomerase II poison etoposide leads to an increased juxtaposition of AML1 and ETO genes on the surface of nucleoli
Mikhail Rubtsov
Novel functions for ubiquitylation in nuclear processes
Catherine Dargemont
13:10-14:00 Lunch
14:00-16:00 Session 3 DNA damage and cancer
Chairmen: Catherine Dargemont and Rouben Harutyunyan
Poly(ADP-ribose) and PCNA-dependent recruitment of PARG to DNA damage sites
Jean-Cristophe Amé
Apurinic/apyrimidinic (AP) site recognition by poly(ADP-ribose) polymerase 1
and other key proteins of human cells
Olga Lavrik
Embryonal proteoglycans and counteraction to a tumour growth
L. Mkrtchyan
Interaction of PARP2 with DNA structures mimicking DNA repair intermediates
Mikhail Kutuzov
Molecular mechanisms involved in anti-cancer effect of hemorphins
N. Barkhudaryan
16:00-16:40 Coffee Break // Poster session
16:40-19:00 Session 4 Cancer
Chairmen: Olga Lavrik and Michael Aghadjanov
Blood lymphocyte lipids in diverse forms of cancer
Y.V.Tadevosyan
Dependence of cell destiny on the longitude of MAPK/ERK1/2 activation by two homologous chitinase-like proteins, CHI3L1 and CHI3L2
Pavel Areshkov
Parameters of cytokine regulation as additional criteria in immune diagnostics
Z.R. Ter-Pogossian
Oncogenic and anti-oncogenic properties of genes with significantly changed expression in brain tumors
Vadim Kavsan
Hypothalamic cytokine Galarmin is an inhibitor of mesenchymal tumors
K.A Galoian
Iatrogenic aplasia induced by chemotherapy and treatment with “proline rich peptide”
Guevorkian A.G
Friday 14, October
8:00 – 9:00 Breakfast
9:00 – 9:15 Transfer to the National Academy of Sciences
9:15– 10:55 Session 5 Autoimmune and neurodegenerative diseases I
Chairmen: Mikhail Ugrumov and Armen Galoyan
The ITSN1 interactome and its functions
Mykola Dergai
Brain plasticity of exposed to prenatal immobilization stress rats
I.K Sahakyan
High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson’s disease
Lydia Kerkerian-Le Goff
Autoimmune processes in pathogenesis of complex polygenic diseases
A.S. Boyajyan
10:55-11:10 Coffee Break
11:10-12:30 Session 6 Autoimmune and neurodegenerative diseases II
Chairmen: Lidya Kerkerian-Le Goff and Gevorg Gevorkian
Region-specific nitric oxide production in cytosolic and mitochondrial compartments of the rat brain tissues following chronic stress-induced depression-like behaviour
N. Nazaryan
Oxidative modifications of biomolecules upon neurodegenerative processes
L.M. Hovsepyan
Modelling of parkinsonism in mice: mechanisms of neuroplasticity
G. Khakimova
Electrophysiological study of the spinal cord motoneurons on the model of Parkinson’s disease induced by rotenone
J. S. Sarkissian
12:30-13:30 Lunch
13:30-14:30 A guided tour to Matenadaran
14:30-17:30 Session 7 Molecular Biology of Diseases
Chairmen: Patrick Curmy and an Anna Boyajyan
Association of mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol involves catalytic domain of the synthetase and transframe and integrase domains of Pol.
Marc Mirande
Carcinoma in situ of the breast: riddles and controversies
M.D. Kostanyan
Effects of silencing RET/PTC1 junction and in vivo delivery of siRNA-Squalene nanoparticles in human papillary thyroid carcinoma cells
Liliane Massaad-Massade
Results of complex treatment of patients with glial brain tumors with local chemotherapy
LR Harutyunyan
The nucleic acid binding properties of CSD of human YB-1
Patrick Curmi
Comprehensive treatment of locally malignant tumors using radiomodifications
V.H. Hovhannisyan
Mutations in MEFV cause alterations in Neutrophil F-actin and Phagocytosis Dynamics
T. K. Davtyan
17:30-17:45 Coffee Break
17:45-18:45 Round table Collaboration between Armenia and France
Chairmen: Yegor Vassetzky and Marc Lipinski
Participants:
Philippe Kaltenbach, sénateur, vice-président de la Région Ile-de-France, chargé des affaires internationales et européennes
Yegor Vassetzky
Marc Lipinski
18:45 Meeting of the scientific committee of the GDRI // Free time
18.45-20:00 Free time
20:00 Gala Dinner
October 15, Saturday
8:30 – 9:30 Breakfast
9:30—11:00 City sightseeing
11:00-14:00 Tour to Garni and Geghard
14:00-16:00 Free time
16:00-18:00 Tour to Etchmiadzin
18:00 Free time
October 16, Sunday
(for participants flying to Paris)
6:30 – 7:00 Breakfast
7:15 Departure to Airport (flight at 9:50)
The proceedings of the meeting will be published in the "Biopolymers and Cell" journal.
Conference sponsors: CNRS, Armenian Association of Biochemists, Région Ile-de-France